The Manchester sides will avoid each other in the FA Cup quarterfinal round as United visit Wolverhampton, while City to travel to Championship side Swansea City.
Aside from United-Wolves, the other all-Premier League tie will be Watford hosting Crystal Palace.
Millwall will host Brighton & Hove Albion in the other match pitting a Championship team against a Premier League side.
The matches will take place between March 15-18 and can be streamed live in the U.S. on ESPN+.
United's tie with...