Clyde host Cowdenbeath in the Scottish Communities League Cup missing Giuseppe Capuano.
The midfielder is banned while full-back Iain Gray is out following an operation on a foot problem.
Manager Barry Ferguson is looking to make it two wins out of two, but knows his side face a tough test
"Cowdenbeath have a very good manager in Jimmy Nicholl and they have some very good players in their squad so this will be a very tough game," he said.
"We had a very good performance and result against Ayr last weekend but we will need to step things up even further to do anything in this game."
Cowdenbeath welcome back Lewis Milne from suspension and Dean Brett will be included if he proves his fitness after a hamstring problem.
New signing Daniel Jurisic will feature if international clearance comes through from Slovenia.
The Blue Brazil are looking to bounce back from their defeat against Brechin last Saturday and Nicholl said: "We started well and got a goal ahead but after we failed to get another we got frustrated.
"We made a mistake and Brechin got level to force extra-time.
"Clyde will be very difficult opponents, it was disappointing to go out of one cup and we certainly do not want to go out of two."